Josefina Serrano López
FOTO JOSEFINA SERRANOFOTO JOSEFINA SERRANO

Josefina Serrano López

SPECIALIST PHYSICIAN IN HEMATOLOGY AND HEMOTHERAPY
Hematología y Hemoterapiaen/specialities/hematologia-hemoterapia

CV Médicos biobuilder con centros Josefina Serrano López

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Key information

  • Extraordinary Doctoral Thesis Award
    1999
  • Latest Publication:
    A case of atypical myelodysplastic syndrome with a novel reciprocal translocation t(1.12)(q21.p13).
  • Belongs to:
    Asociación Andaluza de Hematología y Hemoterapia

Professional Details

Hospital Quirónsalud Córdoba
SPECIALIST PHYSICIAN HAEMATOLOGY AND HAEMOTHERAPY
January 2021 - Present
Hospital Reina Sofía
Researcher
July 2003 - Present
Hospital Universitario de Cáceres
Medical care
January 1998 - January 2000
Hospital Universitario Fundación Jiménez Díaz
Medical care
January 1998 - January 2000
Study
MEDICINE AND SURGERY
University, Universidad de Córdoba
1991
Doctorate
Universidad de Córdoba
1999
Doctorate
Universidad de Córdoba
1999
Another qualification
Hematology Resident
Molecular study in low-risk acute myeloblastic leukemias
UNIVERSIDAD DE CORDOBA
June 2018
Implications of immunosenescence in the design of NK cell-based antitumor immunotherapy protocols in models of melanoma and acute myeloid leukemia
Maimonides Institute
2017 - 2019
A phase 3, randomized, double-blind, placebo-controlled study to compare the efficacy and safety of oral azacitidine plus best supportive care versus best supportive care as maintenance therapy in patients with acute myeloid leukemia in complete remission
PPD GLOBAL LTD
2013 - 2018
Study for the validation of an ex vivo personalized medicine test in acute lymphoblastic leukemia
VIVIA BIOTECH S.L
2013 - 2017
Effect of clinical and genetic variables on the optimization of antifungal pharmacotherapy through the use of clinical pharmacokinetics
SPANISH SOCIETY OF HOSPITAL PHARMACY
2013 - 2015
Maintenance treatment with 5-Azacitidine in patients with acute myeloblastic leukemia who are not eligible for intensive treatment and who have a partial or complete response following induction chemotherapy
BIOCLEVER 2005, S.L.
2011 - 2014
Multicenter, prospective, open-label, single-arm, phase I-II clinical trial to evaluate induction therapy with a combination of fludarabine, idarubicin, cytarabine, G-CSF, and plerixafor for the treatment of young patients with relapsed or refractory AML
PETHEMA FOUNDATION
2012 - 2014
Multicenter, prospective, open-label, single-arm, phase II clinical trial to evaluate induction therapy with a combination of clofarabine and low-dose cytarabine followed by consolidation therapy with clofarabine and low-dose cytarabine for the treatment of patients aged 60 years or older with AML
PETHEMA FOUNDATION
2011 - 2014
I study Th17 cells in the pathogenesis of Graft-versus-Host Disease after allogeneic hematopoietic precursor transplantation
MINISTRY OF ECONOMY AND COMPETITIVENESS
2010 - 2013
A retrospective multicenter study to describe the effectiveness and safety of clofarabine as a compassionate use treatment in adult patients with relapsed/refractory acute leukemia prior to hematopoietic stem cell transplantation
Andalusian Association of Hematology and Hemotherapy
2013 - 2013
National Registry of Patients Diagnosed with Acute Myeloid Leukemia According to WHO Criteria and Treated with Azacitidine. ALMA
FULCALHH (Castilian-Leonese Foundation of Hematology and Hemotherapy)
2011 - 2011
A multicenter, prospective, non-randomized, Phase I-II trial to assess the efficacy and safety of the combination of oral quizartinib and the FLAG-IDA chemotherapy regimen in first relapsed/refractory acute myeloid leukemia (R/R AML) patients
PETHEMA FOUNDATION
2020 - Present
PEVOLAM: A randomized phase III, multicentre, open label clinical trial comparing azacitidine plus pevonedistat versus azacitidine in Older/Unfit patients with newly diagnosed acute myeloid leukemia who are ineligible for standard induction chemotherapy
PETHEMA FOUNDATION
2019 - Present
Phase III, multicenter, randomized, open-label study of azacitidine (vidaza(r)) versus fludarabine and cytarabine (fluga regimen) in elderly patients with newly diagnosed acute myeloid leukemia
PETHEMA FOUNDATION
2017 - Present
CC-486-AML-001: Phase 3, randomized, double-blind, placebo-controlled study to compare efficacy and safety of oral azacitidine plus best supportive care versus best supportive care as maintenance therapy in subjects with acute myeloid leukemia in complete remission
CELGENE-BSM
2018 - Present
Early Access Program (EAP) of Gilteritinib (ASP2215) in Patients With FMS-like Tyrosine Kinase 3 (FLT3) Mutated Relapsed or Refractory Acute Myeloid Leukemia (AML) or With FLT3-Mutated AML in Complete Remission (CR) With Minimal Residual Disease (MRD)
ASTELLAS SL
2018 - Present
PHASE III, MULTICENTER, RANDOMIZED, OPEN-LAID STUDY OF AZACITIDINE (VIDAZA(r)) VERSUS FLUDARABINE AND CYTARABINE (FLUGA SCHEME) IN ELDERLY PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA
Phase III Randomized, Double-blind, Placebo-controlled Study Investigating the Efficacy of the Addition of Crenolanib to Salvage Chemotherapy Versus Salvage Chemotherapy Alone in Subjects = 75 Years of Age with Relapsed/Refractory FLT3 Mutated Acute Myeloid Leukemia
AROG
2018 - Present
TUD-APOLLO-064: A randomized phase III study comparing arsenic trioxide (ATO) combined with ATRA and idarubicin versus standard ATRA- and anthracycline-based chemotherapy (AIDA) in patients with newly diagnosed high-risk acute promyelocytic leukemia
PETHEMA FOUNDATION
2018 - Present
M19-708: Randomized, Open-label, 2-Arm, Multicenter, Phase 3 Study of Venetoclax and Azacitidine Versus Best Supportive Care as Maintenance Therapy for Patients with Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy (VIALE-M)
ABBVIE SL
2020 - Present
A 2:1 randomized phase II trial to compare the efficacy and safety of standard chemotherapy plus quizartinib versus standard chemotherapy plus placebo in adult patients with newly diagnosed FLT3 wild-type AML
PETHEMA FOUNDATION
2020 - Present
AC220-A-U302 Quantum First: A phase 3, double-blind, placebo-controlled study of Quizartinib (AC220) administered in combination with induction and consolidation chemotherapy, and administered as maintenance therapy in subjects 18 to 75 years old with newly diagnosed FLT3-ITD (+) acute myeloid leukemia
Daiichi Sankyo, Inc.
2019 - Present
PHASE IB/II STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PF 04449913, AN ORAL HEDGEHOG PATHWAY INHIBITOR, IN COMBINATION WITH INTENSIVE CHEMOTHERAPY, LOW-DOSE ARA-C, OR DECITABINE, ADMINISTERED TO PATIENTS WITH ACUTE MYELOID LEUKEMIA OR HIGH-RISK MYELODYSPLASTIC SYNDROME
PFIZER COLLABORATION AGREEMENT COMPUTER TOOL FOR THE DEVELOPMENT AND MAINTENANCE OF THE TOOL FOR THE PROCESSING AND ANALYSIS OF DATA FROM THE STUDY VORICONAZOLE ANTIFUNGAL PROPHYLASIS IN PATIENTS WITH NEUTROPENIA
PFIZER, S.L.U.
A case of atypical myelodysplastic syndrome with a novel reciprocal translocation t(1.12)(q21.p13).
Scientific article
A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia.
Scientific article
A phase I-II study of plerixafor in combination with fludarabine, idarubicin, cytarabine, and G-CSF (PLERIFLAG regimen) for the treatment of patients with the first early-relapsed or refractory acute myeloid leukemia.
Scientific article
A precision medicine test predicts clinical response after idarubicin and cytarabine induction therapy in AML patients.
Scientific article
A prognostic model for survival after salvage treatment with FLAG-Ida +/- gemtuzumab-ozogamicine in adult patients with refractory/relapsed acute myeloid leukaemia.
Scientific article
Acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3.3)(q21.3.q26.2): Study of 61 patients treated with intensive protocols.
Scientific article
Allogeneic bone marrow transplantation vs chemotherapy for the treatment of childhood acute lymphoblastic leukaemia in second complete remission (revisited 10 years on).
Scientific article
Allogeneic Hematopoietic Stem Cell Transplantation Following the Use of Hypomethylating Agents among Patients with Relapsed or Refractory AML: Findings from an International Retrospective Study.
Scientific article
Assessment of hematologic progenitor engraftment by complete reticulocyte maturation parameters after autologous and allogeneic hematopoietic stem cell transplantation.
Scientific article
Atypical chronic graft-versus-host disease following interferon therapy for chronic myeloid leukaemia relapsing after allogeneic BMT.
Scientific article
Autologous peripheral blood stem cell transplantation (PBSCT) mobilized with G-CSF in AML in first complete remission. Role of intensification therapy in outcome.
Scientific article
Autologous reconstitution with BCR-ABL-negative haematopoiesis after T cell-depleted allogeneic BMT for CML.
Scientific article
Characteristics, clinical outcomes, and risk factors of SARS-COV-2 infection in adult acute myeloid leukemia patients: experience of the PETHEMA group.
Scientific article
Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia.
Scientific article
Chemotherapy or Allogeneic Transplantation in High-Risk Philadelphia Chromosome-Negative Adult Lymphoblastic Leukemia.
Scientific article
Clinical and biological prognostic factors in relapsed acute myeloid leukemia patients.
Scientific article
Clinical factors influencing phenotype of HCMV-specific CD8 T cell and HCMV-induced interferon-gamma production after allogeneic stem cell transplantation.
Scientific article
Clinical factors that affect the detection of BCR-ABL transcripts after allogenic bone marrow transplantation for chronic myeloid leukemia.
Scientific article
Clinical value of immunological monitoring of minimal residual disease in acute lymphoblastic leukaemia after allogeneic transplantation.
Scientific article
Clofarabine-based chemotherapy for relapsed/refractory adult acute lymphoblastic leukemia and lymphoblastic lymphoma. The Spanish experience.
Scientific article
Clonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes.
Scientific article
Cytoplasmic localization of wild type survivin is associated to constitutive activation of PI3k/akt signaling pathway and represents a favorable prognostic factor in acute myeloid leukemia patients.
Scientific article
Detection of myeloperoxidase by flow cytometry in acute lymphoblastic leukaemias with BCR-ABL gene rearrangement.
Scientific article
Differences in ex-vivo Chemosensitivity to Anthracyclines in First Line Acute Myeloid Leukemia.
Scientific article
Evolving treatment patterns and outcomes in older patients (>=60 years) with AML: changing everything to change nothing?.
Scientific article
Flow cytometry of cell suspensions from lymph nodes: immunophenotype, DNA content and proliferative rate are strongly correlated with histopathology diagnosis.
Scientific article
Genetic, phenotypic and clinical features of acute lymphoblastic leukemias expressing myeloperoxidase mRNA detected by RT-PCR.
Scientific article
Hypomethylating agents in relapsed and refractory AML: outcomes and their predictors in a large international patient cohort.
Scientific article
Impact of measurable residual disease by decentralized flow cytometry: a PETHEMA real-world study in 1076 patients with acute myeloid leukemia.
Scientific article
Incidence and outcome after first molecular versus overt recurrence in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia included in the ALL Ph08 trial from the Spanish PETHEMA Group.
Scientific article
Increasing mixed haematopoietic chimaerism after BMT with total depletion of CD4+ and partial depletion of CD8+ lymphocytes is associated with a higher incidence of relapse.
Scientific article
Invasive fungal disease in children with haematological malignances and stem cell transplantation recipients.
Scientific article
Kinetic of regulatory CD25high and activated CD134+ (OX40) T lymphocytes during acute and chronic graft-versus-host disease after allogeneic bone marrow transplantation.
Scientific article
Long-term survival after intensive chemotherapy or hypomethylating agents in AML patients aged 70 years and older: a large patient data set study from European registries.
Scientific article
Machine learning applied to gene expression analysis of T-lymphocytes in patients with cGVHD.
Scientific article
Measurable residual disease in elderly acute myeloid leukemia: results from the PETHEMA-FLUGAZA phase 3 clinical trial.
Scientific article
Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210(BCR-ABL) and p190(BCR-ABL) after allogeneic bone marrow transplantation for chronic myeloid leukemia: increasing mixed myeloid chimerism and p190(BCR-ABL) detection precede cytogenetic relapse.
Scientific article
Myeloid mixed chimerism is associated with relapse in bcr-abl positive patients after unmanipulated allogeneic bone marrow transplantation for chronic myelogenous leukemia.
Scientific article
Myeloperoxidase gene expression in non-infant pro-B acute lymphoblastic leukaemia with or without ALL1/AF4 transcript.
Scientific article
Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project.
Scientific article
Nonleukemic myeloid dendritic cells obtained from autologous stem cell products elicit antileukemia responses in patients with acute myeloid leukemia.
Scientific article
Oral decontamination with aminoglycosides is associated with lower risk of mortality and infections in high-risk patients colonized with colistin-resistant, KPC-producing Klebsiella pneumoniae.
Scientific article
Outcome of Antifungal Combination Therapy for Invasive Mold Infections in Hematological Patients is Independent of the Chosen Combination.
Scientific article
Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study.
Scientific article
Performance of the Medical Research Council (MRC) and the Leukemia Research Foundation (LRF) score in predicting survival benefit with hypomethylating agent use in patients with relapsed or refractory acute myeloid leukemia.
Scientific article
Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine.
Scientific article
Prevention of graft-versus-host disease in high risk patients by depletion of CD4+ and reduction of CD8+ lymphocytes in the marrow graft.
Scientific article
Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens.
Scientific article
Prospective randomized trial of 5 days azacitidine versus supportive care in patients with lower-risk myelodysplastic syndromes without 5q deletion and transfusion-dependent anemia.
Scientific article
Quantification of minimal residual disease levels by flow cytometry at time of transplant predicts outcome after myeloablative allogeneic transplantation in ALL.
Scientific article
Real life outcomes of patients aged >=75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry.
Scientific article
Reticulocyte maturation parameters are reliable early predictors of hematopoietic engraftment after allogeneic stem cell transplantation.
Scientific article
The impact of acute and chronic graft-versus-host disease on normal and malignant B-lymphoid precursors after allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia.
Scientific article
The Mutational Landscape of Acute Myeloid Leukaemia Predicts Responses and Outcomes in Elderly Patients from the PETHEMA-FLUGAZA Phase 3 Clinical Trial.
Scientific article
Treatment of Frail Older Adults and Elderly Patients With Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia: Results of a Prospective Trial With Minimal Chemotherapy.
Scientific article
Treatment of invasive fungal infections in high risk hematological patients. The outcome with liposomal amphotericin B is not negatively affected by prior administration of mold-active azoles.
Scientific article
Treatment patterns and outcomes of 2310 patients with secondary acute myeloid leukemia: a PETHEMA registry study.
Scientific article
Tumor necrosis factor-?-secreting CD16+ antigen presenting cells are effectively removed by granulocytapheresis in ulcerative colitis patients.
Scientific article
Validation of a multivariable prediction model for post-engraftment invasive fungal disease in 465 adult allogeneic hematopoietic stem cell transplant recipients.
Scientific article
Voriconazole as primary antifungal prophylaxis in children undergoing allo-SCT.
Scientific article
Voriconazole as primary antifungal prophylaxis in patients with neutropenia after hematopoietic stem cell transplantation or chemotherapy for acute myeloid leukemia.
Scientific article
Asociación Andaluza de Hematología y Hemoterapia
Grupo de Investigación GC-16 Biología Celular en Hematología
Grupo Andaluz de Leucemias Agudas (Gala)
PETHEMA
Extraordinary Doctoral Thesis Award
Universidad de Córdoba
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