Assisted Reproduction

FIV Reproducción Asistida Ruber

In Vitro Fertilization (IVF) is an assisted reproduction technique designed to increase the chances of pregnancy through hormonal stimulation to obtain eggs, which are then fertilized in the laboratory and transferred to the uterus to achieve pregnancy.

This process aims to produce high-quality embryos that are cultivated in the laboratory under constant supervision and control until they reach the blastocyst stage. The blastocyst with the highest implantation potential is then selected and transferred to the maternal uterus at the optimal time of endometrial receptivity. The blastocyst transfer is a simple vaginal procedure that does not require anesthesia.

En Ruber Internacional estamos orgullosos de ofrecer excelentes tasas de éxito en los tratamientos de Fecundación in Vitro (FIV). Contamos con un equipo de embriólogos altamente cualificados cuya experiencia y conocimiento en la manipulación de los óvulos y espermatozoides, así como en el cultivo y selección de embriones mediante tecnología de vanguardia, como los sistemas de cultivo time-lapse dotados de Inteligencia Artificial, garantizan la máxima calidad en cada paso del proceso de FIV.

At Ruber Internacional, we are proud to offer excellent success rates in IVF treatments. Our team of highly qualified embryologists ensures the highest quality at every step of the IVF process. Their expertise in handling eggs and sperm, as well as in embryo culture and selection using cutting-edge technologies like time-lapse culture systems equipped with artificial intelligence, guarantees outstanding outcomes.

Pregnancy Rates

At Ruber Internacional, we take pride in our excellent IVF results. Our success rate for women under 35 years old is among the highest, reaching a 60% pregnancy rate after the first embryo transfer. Additionally, our cumulative success rate is 73% after transferring all embryos from the same cycle (cumulative rate). This cumulative rate includes pregnancies achieved from both fresh embryo transfers and transfers of cryopreserved embryos from the same cycle.

The chances of achieving pregnancy with IVF treatment can increase with multiple cycles of treatment. For women under 38 years old, the pregnancy rate after three IVF cycles can exceed 90%.

IVF is a highly effective assisted reproduction technique that has provided many women and couples with the opportunity to fulfill their dream of having a baby. However, the woman’s age is a crucial factor in IVF success rates with her own eggs. As women approach 40 years old, the chances of pregnancy in a single IVF cycle decrease significantly.

For women close to 40 years old, the IVF success rate with their own eggs is approximately 42%. After 40, the chances of pregnancy decrease even further.

It is important to note that these statistics are general, and each patient is unique. Success rates may vary depending on other reproductive health factors and individual responses to treatment.

Types of IVF Treatments

IVF treatments can vary based on the source of the gametes involved, whether eggs or sperm:

• IVF with the patient’s own eggs and partner’s sperm
• IVF with the patient’s own eggs and donor sperm
• IVF with donor eggs and partner’s sperm
• IVF with donor eggs and donor sperm

PGT-A Biopsia de embrión

Preimplantation Genetic Testing (PGT) is a complementary technique to assisted reproduction methods that allows the detection of different genetic alterations in embryos before their transfer to the maternal uterus. There are several main types of PGT:

• PGT-A (Preimplantation Genetic Testing for Aneuploidy Detection): This test detects whether embryos have an abnormal number of chromosomes, which can lead to genetic disorders. It is indicated for older women, those with a history of miscarriages or previous failed IVF treatments, as well as in cases of male factor infertility.
• PGT-M (Preimplantation Genetic Testing for Monogenic Disease Detection): This test detects the presence of a mutation in a specific gene that causes hereditary autosomal recessive, autosomal dominant, or X-linked diseases. It is suitable for couples who carry a genetic disease, have a family history of genetic diseases, or have been diagnosed with a genetic disorder.
• PGT-SR (Preimplantation Genetic Testing for Structural Alteration Detection): This test detects structural alterations in chromosomes, such as translocations, deletions, or duplications, which can lead to genetic diseases or fertility problems. It is appropriate for couples where one member is a carrier of a chromosomal alteration.

The PGT process involves an In Vitro Fertilization (IVF) cycle, where eggs are obtained and fertilized with the partner's or a donor's sperm. The resulting embryos are cultured to the blastocyst stage, and an embryo biopsy is performed to genetically analyze the cells.

Once the results report is obtained, healthy embryos or those free from the genetic disease are selected for transfer to the maternal uterus. The remaining healthy embryos are cryopreserved for future attempts.

At Ruber Internacional, our embryologists are highly qualified and have extensive experience in performing embryo biopsies, in which 8 to 15 cells are extracted from the outer layer of the blastocyst (trophoectoderm) for genetic analysis. The extracted cells are placed in a special tube (tubing) that will allow for precise genetic analysis.

Our advanced technology and expertise in PGT enable us to offer precise and reliable results.

ni PGT-A no invasivo

Non-Invasive Preimplantation Genetic Testing (niPGT-A) is a genetic analysis method that evaluates embryos in the laboratory without the need for biopsy. The embryos are cultured until day 5-7 of development, when they reach the blastocyst stage, and a drop of the surrounding culture medium is collected to analyze the cell-free DNA derived from the embryo present in the medium.

By analyzing this DNA from the culture medium, it is possible to assess the chromosomal content of the embryos in a non-invasive manner, classifying and ordering them based on their likelihood of being euploid (chromosomally normal). This allows us to prioritize the transfer of embryos with the highest chances of resulting in a healthy pregnancy.

Among the advantages of niPGT-A are:

• Greater precision in embryo selection: It allows for the identification of embryos with the highest probability of being healthy, increasing the chances of a successful pregnancy and a healthy baby born at home. It also reduces the number of transfers needed and shortens the treatment duration.
• Avoids manipulation and biopsy of the embryos.
• Reduction in clinical costs: Since no embryo biopsy is required, niPGT-A reduces the cost of treatment.

The niPGT-A test is particularly indicated for patients with recurrent miscarriages, implantation failures, older women, men with chromosomal abnormalities in their sperm, and patients whose embryos are not of sufficient quality to undergo biopsy. However, it is available for all patients undergoing in vitro fertilization treatment, offering a more informed and personalized decision-making process during treatment, thus increasing the likelihood of having a healthy baby at home.

Preservación de la fertilidad

Female fertility preservation is an option for women who wish to delay motherhood for personal, social, or work-related reasons. With age, female fertility significantly decreases in both the quantity and quality of eggs, especially after the age of 35. However, through the technique of vitrification, it is possible to freeze "young" eggs and use them in the future when the woman decides to have a baby, maintaining the same chances of pregnancy as at the time of preservation.

In our assisted reproduction laboratory, we use state-of-the-art techniques and follow strict protocols to ensure that the eggs are treated with the utmost care throughout the vitrification and preservation process.

The fertility preservation process involves several steps:

• Ovarian Stimulation:

The treatment begins during the menstrual cycle with the administration of hormones to stimulate the development of multiple eggs in the ovaries.

• Monitoring and Control:

During ovarian stimulation, ultrasounds and blood tests are performed to monitor the growth and maturation of the eggs.

• Ovulation Induction:

When the eggs reach the appropriate size and maturity, a dose of hCG hormone is administered to induce ovulation.

• Ovarian Aspiration:

Approximately 36 hours after ovulation induction, an ovarian aspiration is performed under sedation to extract the eggs from the ovaries.

• Vitrification:

The extracted eggs are processed and subjected to a specific "freezing" technique called vitrification. They are treated with protective media and then placed in small supports that are immersed in liquid nitrogen at a temperature of -196°C.

• Storage:

The vitrified eggs are stored in tanks at extremely low temperatures, with a double alarm system to ensure that the temperature remains constant.

When should I vitrify my eggs?

Fertility preservation is recommended for women who wish to delay motherhood and is most effective before the age of 35. As a woman ages, the quality of her eggs declines, affecting the chances of future pregnancy. However, vitrification offers very high survival rates and does not negatively affect success rates in reproductive treatments when performed before the age of 35.

Trust our experience to protect your future and preserve your dream of becoming a mother.